BMC Infectious Diseases 2009, 9:130doi:10.1186/1471-2334-9-130
Research article
1 Department of Preventive Health Care, SINTEF Technology and Society, Trondheim, Norway
2 Department of Mathematical Sciences, Faculty of Information Technology, Mathematics and Electrical Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
3 Regional Centre for Child and Adolescent Mental Health, Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
The electronic version of this article is the complete one and can be found online at:
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Published : 14 August 2009
© 2009 Bakken and Ghaderi; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chlamydia trachomatis is a highly prevalent sexually transmitted disease. Testing rates among young Norwegian women are high. Young women diagnosed with C. trachomatis are often worried about future complications.
Our cohort consisted of 24,947 women born 1970–1984 who were tested for C. trachomatis infection during 1990–2005. We linked C. trachomatis laboratory data to data on hospitalizations for pelvic inflammatory disease during 1990–2005. Cox regression analysis with time-dependent covariates adjusted for age at first test was used to assess the association between C. trachomatis history and pelvic inflammatory disease.
Follow-up until the end of 2005 included 201,387 woman-years. The incidence rate of hospitalization for pelvic inflammatory disease was higher among women with prior C. trachomatis infection than among women with negative tests only (48 events during 32,057 person-years and 143 events during 169,192 person-years, corresponding to 0.15 and 0.08 per 100 person-years, respectively). The corresponding hazard ratio adjusted for age at first test was 1.69 (95% CI, 1.21–2.36).
Our data show a link between a diagnosis of C. trachomatis infection and subsequent pelvic inflammatory disease. However, pelvic inflammatory disease was a rare event irrespective of C. trachomatis status. These, together with other recent findings, can be used to reassure women worried about their future reproductive health following a diagnosis of C. trachomatis.
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