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Chlamydia


JAC Advance Access originally published online on February 25, 2003

Journal of Antimicrobial Chemotherapy (2003) 51, 1025-1028
© 2003 The British Society for Antimicrobial Chemotherapy

 

Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia


Margaret R. Hammerschlag 1, Tamara Reznik 1, Patricia M. Roblin 1, Julio Ramirez 2, James Summersgill 2 and Stanley Bukofzer 3

  1. Departments of Pediatrics and Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York, NY 11203-2098;
  2. Department of Medicine, University of Louisville, Louisville, KY;
  3. Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL, USA

 

Received 22 October 2002; returned 13 December 2002; revised 24 December 2002; accepted 15 January 2003

 

 

© The British Society for Antimicrobial Chemotherapy
Reprinted with permission of Oxford University Press and The British Society for Antimicrobial Chemotherapy

 

Abstract:

 

Nasopharyngeal specimens for culture of Chlamydia pneumoniae were obtained from patients with community-acquired pneumonia enrolled in a randomized study comparing the novel ketolide antibiotic ABT-773 at a dose of 150 mg once a day to 150 mg twice a day, by mouth for 10 days.

C. pneumoniae was eradicated from the nasopharynx of 10 of 10 (100%) microbiologically evaluable patients. MICs and MBCs for 13 isolates of C. pneumoniae from 12 patients obtained before and after therapy were performed against ABT-773. The MIC90 and MBC90 of ABT-773 were 0.015 mg/L.

 

Copyright © The British Society for Antimicrobial Chemotherapy
http://jac.oxfordjournals.org/


Full Text Article at: http://jac.oxfordjournals.org/cgi/content/full/51/4/1025

 

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