JAC Advance Access originally published online on August 13, 2003
Journal of Antimicrobial Chemotherapy (2003) 52, 497-499
© 2003 The British Society for Antimicrobial Chemotherapy
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan
Received 14 February 2003; returned 15 April 2003; revised 13 June 2003; accepted 17 June 2003
© The British Society for Antimicrobial Chemotherapy
Reprinted with permission of Oxford University Press and The British Society for Antimicrobial Chemotherapy
Objectives: To investigate the in vitro activity of cethromycin, a new ketolide, against Chlamydia pneumoniae.
Methods: The in vitro activity of cethromycin against 20 isolates of C. pneumoniae was compared with the activities of telithromycin, erythromycin A, azithromycin and clarithromycin against those isolates.
Results: The MIC at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of the isolates were killed by cethromycin were both 0.016 mg/L (range 0.016-0.031 mg/L). Cethromycin was the most active antibiotic tested in this study.
Conclusions: Our results appear to indicate that cethromycin is an effective antibiotic that should play some role in the treatment of respiratory tract infections caused by C. pneumoniae
Copyright © The British Society for Antimicrobial Chemotherapy
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Full Text Article at: http://jac.oxfordjournals.org/cgi/content/full/52/3/497
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