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Chlamydia


Journal of Clinical Pathology 2002;55:218-220
© 2002 Journal of Clinical Pathology

ORIGINAL ARTICLE

 

Chlamydia pneumoniae in infrequently examined blood vessels

 

D Taylor-Robinson 1, B J Thomas1, R Goldinn 2 and R Stanbridge 3

 

  1. Department of Genitourinary Medicine, Imperial College School of Medicine, St Mary's Campus, Paddington, London, UK
  2. Department of Histopathology, Imperial College School of Medicine
  3. Department of Cardiovascular Surgery, St Mary's Hospital, Paddington, London W2 1NY, UK

Correspondence to: Professor D Taylor-Robinson, 6 Vache Mews, Vache Lane, Chalfont St Giles, Buckinghamshire HP8 4UT, UK


Accepted for publication 20 September 2001


Reprinted with expressed permission of the BMJ Publishing Group
Copyright © Journal of Clinical Pathology

Abstract

Aim: To determine the prevalence of Chlamydia pneumoniae DNA in infrequently examined blood vessels.

Methods: Vessels obtained from 15 men and six women at coronary artery bypass surgery were tested by a nested polymerase chain reaction (PCR) assay for C pneumoniae DNA.

Results: Chlamydia pneumoniae DNA was detected in four of six atheromatous ascending aorta specimens but in none of eight non-atheromatous aorta specimens, in six of 11 atheromatous internal mammary artery specimens but in none of seven non-atheromatous internal mammary artery specimens, in five of seven long saphenous vein specimens showing evidence of disease but in none of 12 specimens without evidence of disease, and in two of three previously grafted veins. Overall, C pneumoniae occurred significantly more often in diseased than in normal vessels (p = < 0.00001).

Conclusions: Chlamydia pneumoniae is often present in diseased areas of arteries, including the internal mammary arteries, and even in diseased areas of veins. It is not present in apparently healthy areas of either type of vessel

 

Copyright © Journal of Clinical Pathology by BMJ Publishing Group.
http://jcp.bmjjournals.com/

 

Full article at : http://jcp.bmjjournals.com/content/55/3/218 ( Free Registration Required )


or at PubMedCentral : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769606/

 

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